颅内间叶性软骨肉瘤病理分析

Pathological analysis of intracranial mesenchymal chondrosarcoma

目的:探讨颅内间叶性软骨肉瘤的临床病理特征、免疫表型特点及鉴别诊断。方法:对1例颅内间叶性软骨肉瘤的临床资料、影像学、组织学形态和免疫表型进行分析,并复习相关文献。结果:间叶性软骨肉瘤镜下肿物由小圆形肿瘤细胞和高分化软骨病变构成,并可见血管外皮瘤样病变区。免疫组化显示小圆形瘤细胞CD99阳性,S-100阴性;软骨区S-100阳性,CD99阴性。结论:颅内间叶性软骨肉瘤非常罕见,其发生多与脑膜和颅骨有关,其确诊需临床、影像、免疫表型和组织形态学四结合。

Objective： To discuss the pathologic features,immunophenotype and its differential diagnosis of mesenchymal chondrosarcoma occurring in intra-calvairum.Methods： Clinical and imageological data,morphology and immunophenotype of an mesenchymal chondrosarcoma occurring in intra-calvairum and relevant literature were reviewed.Results： Microscopically,the mesenchymal chondrosarcoma consisted of small and round tumor cells as well as well differentiated cartilage island.In addition,lesion looked like hemangiopericytoma can be observed in this case.Immunohistochemistry detection revealed that small and round tumor cells were positive for CD99,but negative for S-100;while the cartilage islands were positive for S-100,but negative for CD99.Conclusions： The onset of intracranial mesenchymal chondrosarcoma,which is rare,involves the meninx and skull.Its diagnosis mainly relied on combined consideration of clinic manifestation,imagological and histopathlogical data as well as immunophenotype.