川芎嗪治疗糖尿病周围神经病变160例临床观察

Clinical effects of ligustrazine on diabetic peripheral diseases

目的:探讨川芎嗪联合甲钴胺治疗糖尿病周围神经病变的疗效。方法:选择住院部收治的2型糖尿病合并周围神经病变患者160例,随机分为2组,治疗组80例,对照组80例,对照组在糖尿病的常规治疗基础上给予甲钴胺,治疗组在对照组的基础上加用川芎嗪。治疗2周后评估疗效。结果:对照组显效16例,有效28例,总有效率为55.0%;治疗组显效36例,有效30例,总有效率为82.5%。两组间的显效例数及总有效率差异有统计学意义(P<0.05和P<0.01)。结论:川芎嗪联合甲钴胺治疗糖尿病神经病变相比单用甲钴胺的有效率,特别是显效率更高,具有良好的疗效,同时没有严重的药物不良反应,值得进一步推广。

Objective： To investigate the clinical effects of ligustrazine on diabetic peripheral diseases.Methods： A total of 160 hospitalized type 2 diabetes patients with peripheral neuropathy were randomly divided into treatment group and control group with 80 patients in each.Based on conventional therapy,the treatment group was also given methylcobalamin;while the treatment group was given ligustrazine.Efficacy assessment was executed after 2 weeks of treatment.Results： Sixteen patients in the control group showed obvious effects,28 patients showed effects showing an total efficacy of 55.0%.The corresponding number of the treatment group was 36,30 and 82.5%,significant higher than the control group（P〈0.05 or 0.01）.Conclusions： Ligustrazine combing with methylcobalamin shows better efficacy than methylcobalamin alone on diabetic peripheral diseases.With no severe side effects,the therapy is worth for application in large scale.