紫外分光光度法测定盐酸奈必洛尔片的含量

Determination of nebivolol hydrochloride tablets by ultraviolet spectrophotometry

目的:建立盐酸奈必洛尔片剂含量的紫外分光光度测定法。方法:采用紫外分光光度法,以0.1mol/mL盐酸为空白对照,280nm为测定波长,测定盐酸奈必洛尔片的含量。结果:盐酸奈必洛尔在20.32～60.96μg/mL范围内线性关系良好(r=0.999 9,n=5),平均加样回收率为100.9%,RSD为1.14%(n=6)。结论:该方法操作简便、精密度好、结果可靠,适用于盐酸奈必洛尔片含量的快速测定。

Objective： To establish ultraviolet spectrophotometry method for the determination of nebivolol hydrochloride tablets.Methods： The content of nebivolol hydrochloride were determined at 280 nm with 0.1 mol/mL hydrochloric acid as the blank control by ultraviolet spectrophotometry.Results： The nebivolol hydrochloride concentration was in the range of 20.32-60.96 μg/mL,and had a good linear relationship（r=0.999 9,n=5）,the average recovery was 100.9% with the RSD of 1.14%（n=6）.Conclusions： This method is simple,of good precision.It is reliable rapid determination method for nebivolol hydrochloride tablets.