取代牛磺酸的合成研究进展

Research progress on the synthesis of substituted taurines

牛磺酸和取代牛磺酸既是一类重要的天然氨基酸,也是天然蛋白氨基酸的含硫类似物,具有重要的生理活性。结合作者课题组的研究工作介绍了近年来取代牛磺酸的合成研究进展,特别是作者课题组发展的多种无盐合成法,可以方便地合成高纯度的取代牛磺酸,包括1-和2-单取代牛磺酸,1,1-,1,2-和2,2-二取代牛磺酸。

Taurine and substituted taurines are a class of key naturally occuring amino acids and the sulfur analogs of protein encoded amino acids with important biological activities. The synthetic methods for various substituted taurines,including 1 - and 2-monosubstituted taurines, 1,1 -, 1,2-, and 2,2- disubstituted taurines,especially salt-free methods for convenient preparation highly pure taurines from the author＇s research group, have been reviewed.