N-取代(4R,7S)-4-甲基-7-异丙基己内酰胺的合成研究

Synthesis of N-substituted(4R,7S)-7-isopropyl-4-methylazepan-2-one

从薄荷酮出发经肟化反应,贝克曼重排反应,以及酰基化反应,合成了一系列标题化合物,其中N-乙酰基取代的产物的产率高达94.8%。通过1HNMR和13CNMR对各步产物进行了表征。

A series of N-substituted （ 4R, 7S ） -7-isopropyl-4- methy]azepan-2-one was synthesized from menthone via oxi- mation,beckmann rearrangement and acyiation. The yield of the acetylation was up to 94.8%. The structures of the products were confirmed by ^1HNMR and ^13 CNMR.