对叔丁基杯[n](n=6,8)芳烃O-烃基化衍生物的微波辐射合成

Synthesis of O-alkylation of p-tert-butylcalix[n]arenes(n=6,8) assisted with microwave irradiation

在微波辐射条件下,以对叔丁基杯[6]、杯[8]芳烃为原料,采用氯化苄、碘代正丁烷、溴代正戊烷为烃基化试剂,PEG-400为催化剂,制备了标题化合物,通过IR、1HNMR光谱对产物的结构进行表征。微波辐射约5 min,即可得到收率中等(40%～66%)的对叔丁基杯芳烃O-烃基化衍生物。结果表明微波辐射法操作简单、反应时间大大缩短、污染明显减少。

To probe into the feasibility of efficiently synthesi- zing O-alkylated ealix[ n ] arene derivatives. Under microwave irradiation condition, six fully O-aikyiated calix[ n] arene derivatives were efficiently synthesized by using p-tert-butylca]ix [ n ] arenes （ n = 6,8 ） with some alkylating reagents such as benzyl chloride, 1-iodobutane, 1-bromopentane. Structures of those compounds were also characterized by the IR and ^1HNMR. The reaction time was about 5 min. the moderate yields of from 40% to 60% were obtained. The results showed the method of microwave irradiation for the preparation of functional O-alkyated calix [ n ] arene derivatives was simple, efficient and reaction time-saving.