谷胺酰胺颗粒灌肠对溃疡性结肠炎患者IFN-γ、IL-4、IL-8的影响及疗效观察

Effect of glutamine granules enema on IFN-γ,IL-4,IL-8 in patients with ulcerative colitis and observation of clinical efficacy

目的探讨谷胺酰胺颗粒灌肠对溃疡性结肠炎患者IFN-γ、IL-4、IL-8的影响及疗效观察。方法 80例溃疡性结肠炎患者随机分为观察组和对照组各40例,观察组给予谷胺酰胺颗粒灌肠,对照组给予柳氮磺胺吡啶保留灌肠,疗程4周,观察比较2组的疗效及IFN-γ、IL-4、IL-8的变化。结果经过4周的治疗,治疗组的总有效率为95.0%,对照组的总有效率为70.0%,2组总有效率比较差异有统计学意义(P<0.05);2组患者治疗前IFN-γ、IL-4、IL-8分别比较,差异无统计学意义;治疗4周后,IFN-γ、IL-8均明显降低,且治疗组与对照组比较,差异有统计学意义(P<0.05);治疗4周后,IL-4的表达水平较治疗前明显增加,差异有统计学意义(P<0.05);2组间比较,差异有统计学意义(P<0.05)。结论谷胺酰胺颗粒灌肠治疗溃疡性结肠炎,能降低血清细胞因子IFN-γ、IL-4、IL-8,可能参与UC的发病机制之一。

OBJECTIVE To investigate the effects and efficacy of glutamine granules enema on ulcerative colitis patients with IFN-γ,IL-4,IL-8. METHODS A total of 80 patients with ulcerative colitis were randomly divided into two groups and the control group 40 cases observed were given glutamine granules enema,the control group received sulfasalazine enema for 4 weeks,cases were evaluated and observed IFN-γ,IL-4,IL-8 changes. RESULTS After 4 weeks of treatment,the total effective rate of the treatment group,was 95.0% but in the control group the total effective rate was 70.0%,total effective difference between the two groups was significant（P〈0.05）.Two groups of patients before IFN-γ,IL-4,IL-8,respectively,the difference was not significant;After 4 weeks,IFN-γ,IL-8 were significantly reduced,and the treatment group and control group,the difference was statistically significant.After 4 weeks of treatment,IL-4 expression levels increased significantly compared with before treatment,the difference was significant.Between the two groups,the difference was significant. CONCLUSION Ulcerative colitis enema treated by glutamine granules can reduce serum cytokines IFN-γ,IL-4,IL-8,which may be involved in the pathogenesis of UC.