摘要
探讨了核糖体小亚基二级结构对真菌系统发育分析的影响。对用不同方法构建的系统发育树进行比较,结果表明结合二级结构信息的分析方法较传统方法产生了更为合理的拓扑结构。二级结构信息除用于优化序列比对外,还需整合到核酸替代模型中;恰当的序列比对方法、进化模型和建树运算法则有助于更加准确地揭示类群之间的亲缘关系。
Different methods using rRNA secondary structure to assist phylogenetic analyses have been recently developed.In order to evaluate the structure information on accuracy of phylogenetic tree topology,comparisons of these methods were performed.Our results showed significant superiority of phylogenetic analyses incorporating secondary structure over the pure traditional approaches.When the three major factors,alignment method,evolutionary model and tree search algorithm,were considered simultaneously in phylogenetic analyses,the implementation of structure information in alignment and substitution model produced a noticeable positive effect on topological accuracy.
出处
《菌物学报》
CAS
CSCD
北大核心
2011年第6期912-919,共8页
Mycosystema
基金
Supported by the Talent Grant of Southwest University of Science and Technology to CYL
the National Natural Science Foundation of China (No. 31070015)
the Knowledge Innovation Program of the Chinese Academy of Sciences (No. KSCX2-EW-J-6) to WYZ
关键词
系统发育
序列分析
拓扑结构
phylogeny
sequence analysis
topological accuracy