杂合子家族性高胆固醇血症患者的内分泌功能研究

A STUDY OF ENDOCRINOL FUNCTIONS IN THE HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA

作者以家族史及淋巴细胞低密度脂蛋白(LDL)受体活力测定诊断家族性高胆周醇血症观察了25例杂合子FH患者的内分泌功能。结果表明,甲状腺素、胰岛素,C肽水平变化不明显,生长激素、皮质醇含量增高,雌激素水平降低,但睾酮水平在男性下降,女性升高。前列腺素代谢物血栓素B_2增高约5倍,血栓素B_2和6酮比例上升2.5倍。这些变化可能加重了LDL受体功能遗传缺陷所致高胆固醇血症诱发的动脉粥样硬化损伤。

The cases of familial hypercholesterolemia were dinosed according of familial history and determination of lymphocyted LDL receptor activity.The endocrinol functions of 25 cases of heterozygous familial hypercholesterolemia were observed. The results showed that there were no significant changes in the levels of thyroxine, insulin and C-peptide. However, the levels of growth hormone and cortisol were increased; estradiol was decreased; testosterone was elevated in females but reduced in males. Regarding prostaglandin metabolites, the mean thromboxane B_2 (TXB_2) level was approximately 5 times higher and the ratio of the TXB_2/6-ketone was 2.5 times higher. These alterations in endocrinol functions may aggravate the atherogenesis on the basis of hypercholesterolemia induced by genetic defect in the LDL receptor function.