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^1H-MRS在AIDS相关痴呆临床应用 被引量：7

Study of 1H-MR spectroscopy in AIDS related dementia
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摘要 目的:探讨1 H-MRS在AIDS痴呆的临床价值。方法:对成人AIDS痴呆患者脑轴面T2WI,T1WI,DWI以及左侧顶叶、右侧基底核团、右侧海马进行单体素MRS扫描。根据HAD分期分为二组,A组1期以下,B组2期以上,C组为正常对照组。结果:共扫描15例AIDS患者,A组10例,B组5例,C组6例。A组顶叶NAA/Cr平均值为0.942,Cho/Cr为0.479,A组海马NAA/Cr平均值为0.607,Cho/Cr为0.774,A组基底节区NAA/Cr平均值为0.723,Cho/Cr为0.573;B组顶叶NAA/Cr平均值为0.828,Cho/Cr为0.544,B组海马NAA/Cr平均值为0.748,Cho/Cr为0.864,B组基底节区NAA/Cr平均值为0.602,Cho/Cr为0.676;C组顶叶NAA/Cr平均值为1.02,Cho/Cr为0.527,C组海马NAA/Cr平均值为0.908,Cho/Cr为0.55,C组基底节NAA/Cr平均值为0.728,Cho/Cr为0.482。结论:MRS能反映AIDS痴呆患者脑内代谢变化,与正常人相比AIDS痴呆患者中顶叶、海马及基底节区NAA/Cr减低,但不能作为诊断AIDS痴呆分期的依据。 Objective：To study the role of 1 H-MR spectroscopy in AIDS related dementia patients. Methods：3.0T MR scanner was used with axial plane T2WI,3D iso-voxel T1WI,diffusion weighted imaging （DWI） and single voxel MR spec- troscopy （MRS） of left parietal lobe,right basal ganglion, right hippocampus. The patients were divided into 2 groups ac- cording to HIV associate dementia （HAD） staging,as group A （〈1）,group B （〉1）,Group C were healthy volunteers as control. Results：Altogether there were 15 AIDS patients with group A （10 patients）, group B （5 patients）, and group C （n= 6）. For group A, the mean value of NAA/Cr of parietal lobe was 0. 942, Cho/Cr was 0. 479;the mean value of NAA/Cr of hippocampus was 0. 607, Cho/Cr was 0. 774; the mean value of NAA/Cr of basal ganglion was 0. 723, Cho/Cr was 0. 573. For group B, the mean value of NAA/Cr of parietal lobe was 0. 828 ,Cho/Cr was 0. 544 ;the mean value of NAA/Cr of hippocampus was 0. 748, Cho/Cr was 0. 864; the mean value of NAA/Cr of basal ganglion was 0. 602, Cho/Cr was 0. 676. For group C, the mean value of NAA/Cr of parietal lobe was 1.02, Cho/Cr was 0. 527;the mean value of NAA/Cr of hippocampus was 0. 908,Cho/Cr was 0.55;the mean value of NAA/Cr of basal ganglion was 0. 728,Cho/Cr was 0. 482. Conclusion：The NAA/Cr decreased in the parietal lobe,hippocampus and basal ganglion of AIDS related dementia patients, and Cho/Cr increased,which proved that the changed cerebral metabolism of AIDS related dementia patients could be dis- played by 1 H-MR spectroscopy. But the data at present could still not used as the criteria for the clinical diagnosis of AIDS related dementia.
作者 齐石 李宏军 员达 赵晶
机构地区 北京首都医科大学附属北京佑安医院医学影像科
出处 《放射学实践》 北大核心 2011年第10期1032-1035,共4页 Radiologic Practice
关键词 获得性免疫缺陷综合征 艾滋病痴呆复合征 磁共振波谱学 Acquired immunodeficiency syndrome AIDS dementia complex Magnetic resonance spectroscopy
分类号 R445.2 [医药卫生—影像医学与核医学] R593 [医药卫生—内科学]
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参考文献17

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二级参考文献7

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放射学实践
2011年 第10期

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