皮寒药解热镇痛作用及初步安全性研究

Evaluation of Analgesic and Antipyretic Actions of Herba Gueldenstaedtia

目的研究皮寒药解热、镇痛作用及其急性毒性。方法以皮寒药水煎液高剂量组(20 g/kg)、中剂量组(10 g/kg)、低剂量组(5 g/kg)灌胃,分别观察背部皮下注射2,4-二硝基苯酚致大鼠发热的解热作用和冰醋酸致小鼠扭体的镇痛作用;以药物最大耐受量测定皮寒药水煎液的急性毒性。结果皮寒药水煎液低剂量组能显著抑制2,4-二硝基苯酚致大鼠的发热;皮寒药水煎液高剂量组明显减少冰醋酸致小鼠扭体次数;急毒实验动物均未出现中毒和死亡现象。结论皮寒药水煎液有较好的解热、镇痛作用;急性毒性小,安全性较好。

ObjectiveTo study the analgesic and antipyretic actions of the extracts of Herba Gueldenstaedtia. MethodsFever model was made by injecting 2,4-dinitrophenol（DNP） subcutaneously on the rat back,and the pain model was established by acetic acid.The acute toxicity was observed by maximal tolerable dose（MTD）. ResultsThe low dose group of the water solution significantly depressed the fever induced by 2,4-dinitrophenol（DNP） and the high dosage inhibited the pain evidently caused by acetic acid.Experimental animals did not show the toxic reaction and death. ConclusionThe water solution of Herba Gueldenstaedtia has obvious analgesic,antipyretic effects and safety is good.