喹硫平治疗抑郁症的增效作用

Small-dose Quetiapine Augmentation in the Treatment of Depression

目的探讨小剂量喹硫平对文拉法辛治疗无精神病性症状抑郁症的增效作用及安全性。方法将58例无精神病性症状抑郁症患者随机分为对照组(文拉法辛组)及观察组(文拉法辛合并喹硫平组),治疗6周。于治疗前,治疗1,2,6周末分别应用Hami Lton抑郁量表(HAMD)及治疗中出现的症状量表(TESS)评定疗效及不良反应。结果观察组疗效显著好于对照组。观察组治疗各周HAMD评分下降比单用组更为显著(t=3.82,P<0.01)。两组TESS评分无显著差异。结论喹硫平治疗抑郁症增效作用明显且安全。

Objective To explore effects of small-dose Quetiapine augmentation with Venlafaxine in the treatment of depression without psychotic symptoms.Methods A total of 58 patients with depression without psychotics symptoms were randomly assigned to Venlafaxine group and Venlafaxine combined with Quetiapine group for 6 weeks.The treatment effects were assessed by using Hamilton depression scale（HAMD） and the side effect using treatment emergent symptom（TESS） at baseline and week 1,2 and 6.Results The Venlafaxine combined with quetiapine group showed higher efficacy and lower HAMD score than Venlafaxine group（t=3.82 P0.01）.There were no significant differences in TESS between two groups.Conclusion Quetiapine can be effective and safe in adjunctive treatment of patients with depression.