齐拉西酮替换氯氮平治疗精神分裂症50例临床观察

Clinical Eiffcacy Study on Ziprasidone Alternated to Clozapine for 50 Schizophrenia Patients

目的观察齐拉西酮替换氯氮平治疗精神分裂症的临床疗效及不良反应。方法选取我院50例既往服用氯氮平的精神分裂症患者替换为齐拉西酮治疗16周。分别于服齐拉西酮前及服药后2,4,6,8,12,16周末采用简明精神病评定量表(BPRS)评定疗效,服药第16周末采用副反应量表(TESS)评定不良反应。结果患者治疗后6,8,12,16周简明精神病评定量表总分较治疗前显著下降(P<0.05或0.01)。其中45例患者成功替换为单剂齐拉西酮治疗。结论齐拉西酮代替氯氮平治疗精神分裂症疗效肯定,不良反应较少,患者的认知功能得到改善,服药依从性升高。

Objective To explore the efficacy and side effect of Ziprasidone substitutes chlorine nitrogen for schizophrenia patients.Methods A total of 50 patients with schizophrenia took medicines from Clozapine to Ziprasidone 16 weeks,Adoption Brief Psychiatric Rating Scaleb and Treatment Emergent Symptom Scale to assess efficacy and bad reaction respectively before taking Ziprasidone and 2,4 ws,6 ws and 8 ws,12 ws and 16 w end and in 16 w end to adopt the Treatment Emergent Symptom Scale（TESS） to assess side effect.Results The scores of BPRS in 6 ws,the 8 ws,12 ws and 16 w aftertreatment were significantly lower than before tredtment（P0.05 or 0.01）45 among the sufferers successfully substituted for the list to Ziprasidone treatment.Conclusion Ziprasidone has a good efficacy and low side effect,it can improve cognition function and compliance.