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泛素连接酶CUL4A-DDB1复合体参与DNA损伤修复的研究进展

Progress in functional regulation of CUL4A-DDB1 ubiquitin ligase on DNA damage and repair
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摘要 泛素化修饰在DNA损伤信号中发挥重要功能,包括细胞周期监控、DNA修复、细胞衰老和程序性死亡的调控。CUL4A-DDB1泛素连接酶通过DCAFs靶向调控特异性的底物,启动DNA切除修复机制对受损DNA进行修复。近期的研究表明CUL4A-DDB1泛素连接酶协助DNA修复因子与受损DNA的识别,来维持基因组的稳定性和正确性。 Ubiquitylation of protein plays an important role in DNA damage signaling transduction,including cell-cycle control,DNA repair,aging,as well as apoptosis.CUL4A-DDB1 E3 ligase recruits substrates through DCAFs for ubiquitylation and initiates the process of DNA excision repair for the removal of damaged DNA.Recent data suggest that the role of CUL4A-DDB1 E3 ligase is critical in genomic stability by regulating DNA damage,DNA repair,and DNA replication.
作者 谢萍 焦杨 周颖 柳向军 张令强 贺福初
机构地区 清华大学生命科学学院 军事医学科学院放射与辐射医学研究所北京蛋白质组研究中心蛋白质组学国家重点实验室 陕西武警总队医院神经外科
出处 《军事医学》 CAS CSCD 北大核心 2011年第10期791-794,共4页 Military Medical Sciences
基金 国家重大科学研究计划课题(2007CB914601) 国家自然科学基金项目(30800584 30800177)部分资助
关键词 泛素蛋白连接酶类 DNA损伤 DNA修复 泛素化修饰 细胞周期 细胞衰老 ubiquitin-protein ligases DNA damage DNA repair ubiquitylation cell cycle cell aging
分类号 R346 [医药卫生—基础医学]
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参考文献30

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二级参考文献101

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军事医学
2011年 第10期

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