子宫内膜癌126例临床病理与预后分析

A clinicopathologic and prognostic analysis of 126 cases of endometrial carcinoma

目的:探讨子宫内膜癌的临床、病理特点及影响预后的因素。方法:回顾分析了2000年1月至2004年12月5年间山东大学齐鲁医院收治的126例子宫内膜癌患者的临床资料。结果:126例子宫内膜癌患者平均发病年龄53.5岁,获得随访的113例患者3年生存率为85.7%,5年生存率为75.1%,总体生存率为69.7%。多因素分析结果显示,手术病理分期(P=0.009)、组织学分级(P=0.006)、淋巴结转移(P=0.025)、病理类型(P=0.001)与预后显著相关,是影响子宫内膜癌患者总体生存率的独立因素。结论:子宫内膜癌手术病理分期、组织学分级、淋巴结转移、病理类型和预后有显著相关性,是影响患者总体生存率的独立因素。

Objective：To explore the clinicopathologic character for endometrial carcinoma and prognostic factors.Methods：One hundred and twenty-six patients with endometrial carcinoma accepted primary surgical treatment from Jan.2000 to Dec.2004 at Qilu Hospital of Shandong University were analyzed retrospectively.Results：The average age of 126 patients was 53.5 years.The 3-year and 5-year survival rate of 113 patients were 85.7% and 75.1%.The overall survival rate were 69.7%.Prognostic factors were also analysed by the multivariate Cox proportional-hazard model.Forward stepwise elimination according to Cox regression results led to a model containing four independent terms that were predictive of overall survival：FIGO surgical stage（P=0.009）,histological grade（P=0.006）,lymph node involvement（P=0.025）,histological type（P=0.001）.Conclusion：The FIGO surgical stage,histological grade,lymph node involvement and histological type of endometrial carcinoma are able to assess prognosis objectively.