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脯氨酸羟化酶在妇科肿瘤中的研究进展 被引量:7

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摘要 脯氨酸羟化酶(PHD)通过催化缺氧诱导因子(HIF)特定的脯氨酸残基发生羟基化反应从而介导HIF降解,在肿瘤发生、发展过程中起着重要作用。随着研究的深入,通过激活PHD的表达或调节其活性促进HIF-1降解可能作为治疗肿瘤的新靶点。本文将近年PHD在妇科肿瘤中的研究进展做一综述。
出处 《现代妇产科进展》 CSCD 北大核心 2011年第10期831-832,835,共3页 Progress in Obstetrics and Gynecology
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