良性前列腺增生与动脉粥样硬化的关系

A correlation between benign prostate hyperplasia and atheroselerosis

目的探讨良性前列腺增生（BPH）与动脉粥样硬化（AS）的内在联系和发病机制。方法依据前列腺体积（PV）将95例患者分为非BPH组（PV≤20ml）24例和BPH组（PV〉20ml）71例。采用高分辨率彩色多普勒超声测定颈动脉内膜中层厚度（IMT），采集相关数据进行分析。结果BPH组三酰甘油（TG）、超敏C反应蛋白（hsCRP）、空腹血清胰岛素的对数[ln（FINS）]、胰岛素抵抗指数的对数[ln（HOMA—IR）]、IMT均显著高于非BPH组，BPH组的冠心病、脑动脉硬化患病率44％、45％，显著高于非BPH组18％、11％（χ^2=6．532、10．162，均P〈0．05）。相关分析显示PV与ln（FINS）、ln（HOMA—IR）、TG、高密度脂蛋白胆固醇（HDLC）呈正相关（r=0．204、0．196、0．375、0．383，均P〈0．05）。结论BPH与AS具有相关性，胰岛素抵抗、炎性反应和血管内皮功能失调可能是BPH和AS共同的发病机制。

Objective To investigate the correlation between benign prostate hyperplasia （BPH） and atheroselerosis （AS）. Methods 95 cases were divided into two groups based on prostate volume （PV） ： 24 cases with non-BPH （PV≤20 ml） and 71 cases with BPH （PV≥20 ml）. Carotid intinal medial thickness （IMT） was determined by high resolution color Doppler sonography. Results Levels of triglyceride （TG）, hypersensitive C reactive protein （hs CRP）, in fasting insulin [ln （FINS）], in insulin resistance index [ln （HOMA IR）] and IMT in BPH group were significantly higher than in nomBPH group. The morbidity rate of coronary heart disease and cerebral arteriosclerosis in the BPH group enhanced as compared with non BPH group. PV were positively correlated with In（FINS）, In（HOMA IR） ,TG and high density lipoprotein （HDL-C）. Conclusions BPH is closely correlated with AS and their eo-pathogenesis might be insulin resistance, inflammatory reaction and endothelial dysfunction.