犬细小病毒单克隆抗体对犬细小病毒病的临床应用研究

A treatment for canine parvovirus infection using CPV McAb Conjugated with immunoglobin and albumin

采用犬细小病毒单克隆抗体(CPV McAb)配合静脉注射用犬免疫球蛋白及静脉注射用犬血白蛋白,采用股内侧肌肉注射对172例细小病毒病患犬进行临床治疗试验。共治愈140例,治愈率为81.40%。采取以上治疗方案,结合对症支持治疗,发病1d的患犬治愈率90.70%,发病2d的患犬治愈率为85.29%,发病3d的患犬治愈率为56.25%,发病4d的患犬治愈率为72.73%,发病5d的患犬治愈率为77.78%。94.29%的治愈犬(132只)用药后4d内完全康复。采用该治疗方案,进入犬体内的McAb能迅速到达全身各组织,中和淋巴组织及血循环中的病毒,阻止病原复制和扩散;同时,中和反应形成抗原抗体复合物,可促进机体的主动免疫反应,促进患犬逐渐康复。该研究结果对提高犬细小病毒病的临床治疗效果具有积极的应用价值。

172 dogs suffering from canine parvovirus infection were treated with canine parvovirus monoclonal antibody（CPV McAb） ,conjugated with canine immunoglobin and albumin,via musculus vastus medialis injection. In the 172 diseased dogs,140 dogs were recovered, the cure rate was 81.40%. It was showed that the one day sick dogs 90.70% ,two day sick dogs 85.29% ,three day sick dogs was only 56.25% ,while that of four to five day sick dogs reached to 72.73 %. In addition, 90.70 % sick dogs can recovery within four day after treatment. Compared with the other drugs mainly antivirus drugs, canine parvovinus antiserum, and only monoclonal antibody, the compositive treatment improved cure rate obviously. Musculus vastus medialis was near to the inguinal lymphnode,injection at there can make the McAb arrive at lymph tissue quidkly, and counteract the toxin of lymph tissue and bloodcycle, then prevent it from extending,the counteracted CPV and McAb became the antigen antibody compound,which can promote active immunity,then played the role of cure sick dogs.