脐带血间充质干细胞在治疗慢性阻塞性肺疾病方面的研究进展

Umbilical cord blood mesenchymal stem cell in the treatment of chronic obstructive pulmonary disease progress of study

慢性阻塞性肺疾病（COPD）是以慢性气道炎症及渐进的肺实质的毁坏为特征，大部分情况是由于吸烟引起的[1]，居当前世界上死亡原因的第四位，主要是通过摧毁终末支气管及肺泡壁来增加通气量。患者通常死于肺气肿的对症治疗（包括：氧疗、抗感染、止咳化痰、解痉平喘、舒张支气管等）的无效及逐渐出现的呼吸衰竭。人们在不断地寻找治疗COPD的方法，除早期干预及对症支持处理外，肺移植成为主要的根治方法。但随着科学技术的不断发展，干细胞疗法受到了广大研究者的关注，其中脐带血间充质干细胞（UCB-MSCs）治疗COPD尤为瞩目。本文就此项研究的相关进展综述如下。

Chronic obstructive pulmonary disease （COPD） which in the current world fourth to the cause of death,is a chronic airway inflammation and gradual destruction of lung parenchyma as feature, most of the situation is due to smoking causes , mainly by destroying terminal bronchial and alveolar walls, to increase ventilation. Patients usually died of emphysema semeiologically treats （including： oxygen cure, anti-infection, reduce phlegm, smooth wheezing, diastolic spasm of bronchial etc） invalid and gradually appear of respiratory failure . People are constantly looking for treatment method of COPD,in addition to early intervention and semeiologically support in the disposal, lung transplant to become a major radical method. But along with the development of science and technology, stem cell therapy by the mass of the attention, the umbilical cord blood mesenchymal stem cells （MSCs） treatment of COPD UCB-partieularly outstanding. This article reviewed the relevant research progress are as follows.