期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脂联素与慢性阻塞性肺疾病相关性研究进展

Recent progress in relationship between adiponectin and chronic obstructive pulmonary disease
原文传递
导出
摘要 脂联素是脂肪组织分泌的一种新的细胞因子，临床研究已证实其参与了能量代谢过程，与炎症标志物具有相关性，慢性阻塞性肺疾病为一慢性炎症过程，随着病情的进展，出现营养不良，因此考虑脂联素参与了慢性阻塞性肺疾病的病理生理过程。现将脂联素与慢性阻塞性肺疾病关系的研究进展综述如下。 Adiponectin is a novel cytokine secreted from adipose tissue. Clinical observations have demonstrated that Adiponectin is closely related to energy metabolism and possibly is involved in inflammatory pathogenesis. Chronic obstructive pulmonary disease （COPD） is a chronic inflammatory course and companied with malnutrition by the development of the disease. Adiponectin might play important roles in the pathogenesis of COPD. In this review, the recent progress in relationship between adiponectin and COPD will be discussed.
作者 韩书芝 李萍 平芬
机构地区 河北省人民医院呼吸内科
出处 《国际呼吸杂志》 2011年第20期1583-1585,共3页 International Journal of Respiration
关键词 慢性阻塞性肺疾病 脂联素 Chronic obstructive pulmonary disease Adiponectin
分类号 R563.9 [医药卫生—呼吸系统]
  • 相关文献

参考文献23

  • 1Stumvoll M, Tschritter O, Fritsche A,et al. Association of the "F G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity:interaction with family history of type 2 diabetes. Diabetes,2002,51:37 41.
  • 2赵小玲,邓国宝,刘媛莉,邓翠迎,黄联继,郭树清,陈岗梅,黄宜生.2型糖尿病大血管病变中血浆脂联素的变化[J].广东医学,2009,30(1):71-73. 被引量：11
  • 3Tarquini R, I.azzeri C, I.affi D et al. Adiponectin and thecardiovascular system: from risk to disease. Intern Emerg Med, 2007,2 : 165-176.
  • 4Fasshauer M, Klein J, Neumann S, et ah Hormonal regulation of adiponectin gene expression in 3T3 L1 adipoeytes. Biochem Biophys Res Commun, 2002,290: 1084- 1089.
  • 5Kharroubi I, Rasschaert J, Eizirik DL, et al. Expression of adiponectin receptors in pancreatic beta cells. Biochem Biophys Res Commun, 2003,312 : 1118-1122.
  • 6Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab,2002,13 =84 89.
  • 7Berg AH, Combs TP, Du X, et al. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med, 2001,7:947-953.
  • 8Kutter D, Devaquet P, Vanderstocken G,et al. Consequences of total and subtotal myeloperoxidase dcficiency~ risk or benefit ? Acta Haematol, 2000,104 : 10-15.
  • 9Maeda N, Shimomura I, Kishida K,et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med, 2002,81731 737.
  • 10Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med, 2001,7:941- 946.

二级参考文献26

  • 1潘永华,薛耀明,李晨钟,张燕,朱波.脂联素在OLETF大鼠脂肪组织中的表达及意义[J].广东医学,2005,26(9):1197-1199. 被引量：4
  • 2周陵,陈绍良,叶飞,罗俊,林松,单守杰,蒋伏平,段宝祥.冠心病患者血清脂联素与C-反应蛋白关系的研究[J].中国综合临床,2006,22(5):400-401. 被引量：11
  • 3慢性阻塞性肺疾病诊治指南(2007年修订版)[J].中华内科杂志,2007,46(3):254-261. 被引量：1790
  • 4WANG Yu, XU Ai -min, KNIGHT C, et al. Hydroxylation and glycosy lafion of the four conserved lysine residues in the collagenous domain of adiponectin potential role in the modulation of its insulin - sensititing actinrity[J]. J Biol Chem, 2002, 277(22) : 19 521-19 529.
  • 5FRUEBIS J, TSAO T S, JAVORSCHI S, et al. Protoolytic cleavage productof 30 -kDa adipocyte complement -related protein increases fatty acid oxidatim in muscle and causes weight loss in mice[ J]. Proc Natl Acad Sci USA, 2001, 98(4) : 2 006 -2 010.
  • 6VASSEUR F, HELBECQUE N, DINA C, et al. Single - nucleo- tide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte - secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caneasians[J]. Hum Mol C, enet, 2002, 11 (21) : 2 607 -2 614.
  • 7MAEDA N, TAKAHASHI M, FUNAHASHI T, et al. PPARgama ligands increase expression and plasma concentrations of adiponectin, an adipose - derived protein [ J ]. Diabetes, 2001, 50 ( 9 ) : 2094-2099.
  • 8OUCHI N, KIHARA S, ARITA Y, et al. Adiponectin, an adipocyte- derived plasma protein, inhibits endothelial NF - kappaB signaling through a cAMP - dependent pathway [ J ]. Cireulation, 2000, 102(11): 1 296-1 301.
  • 9YAMAUCHI T, KAMON J, WAKI H, et al. The fat -derived hormone adiponectin reverses instdin resistance associated with both lipoatrophy and obesity[J]. Nat Med, 2001, 7(8) : 941 -946.
  • 10Miller M, Cho JY, Pahma A, et al. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J Inununo1,2009 ,182 :684-691.

共引文献28

国际呼吸杂志
2011年 第20期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部