血清C反应蛋白与前白蛋白在早产儿感染早期诊断中的应用研究

目的:探讨血清C反应蛋白(CRP)和前白蛋白(PA)二者在早产儿感染早期诊断中的应用价值。方法:对在我院出生的200例早产儿进行感染监测,在检测其血清CRP和PA水平的同时测定血白细胞总数(WBC)、杆状核白细胞比例。结果:早产儿出现感染时,CRP值明显增高,以8ul/dl为上限值,其诊断敏感性为84%,特异性为97%;出现感染时,PA值明显降低,以正常早产儿PA平均水平的75%和50%为下限值,其诊断敏感性和特异性分别为96%(75%)、88(50%)和83(75%)和95%(50%);出现感染时白细胞总数(WBC)、杆状核白细胞比例均有一定程度升高,其诊断敏感性低于PA,特异性低于CRP。结论:血清CRP和PA水平的结合分析,有助于提高早产儿细菌感染早期诊断的准确性。

Objective：To determine the significance of C-reactive protein（CRP） and prealbumin（PA） for the early diagnosis of infection in preterm newborns.Methods：Serum levels of CRP and PA in 200 newborns of less than 35 weeks ＇ gestational age were examined,accompanying by the counting of the white cell and stab cell.Results：The level of CRP increased dramatically in preterm infants with defined infection.Given the upper limit of 8ul/dl,the sensitivity and specificity of CRP were respectively 84% and 97%.The level of PA decreased dramatically in preterm infants with defined infection.Taking the infants whose PA was reduced by 25%and 50%as the positive subjects,the sensitivity of PA were respectively 96%and 88%while the specificity were 83%and 95%.The sensitivity of white cell and stab cell,which was increased to certain extent was lower than that of PA,while the specificity white cell and stab cell was lower than that of CRP.Conclusions：Comprehensive analysis of the serum level of CRP and PA will benefit the early diagnosis of infection in preterm newborns.