赶黄草与槲皮素预防酒精性脂肪肝的比较研究

Comparative Study on Prevention Effects of Penthorum chinese Pursh.and Quercetin on Alcoholic Fatty Liver

目的比较赶黄草与槲皮素预防酒精性脂肪肝的作用。方法采用加入1.5%的硫酸亚铁饲料进行饲养,应用酒精灌胃方法建立大鼠酒精性脂肪肝模型,造模同时分别给予赶黄草提取物及槲皮素进行药物干预,以TPN为对照,对赶黄草提取物组和槲皮素组大鼠肝脏行病理学检查,检测并比较赶黄草提取物及槲皮素对大鼠血清中谷草转氨酶(ALT)、谷丙转氨酶(AST)、总胆固醇(TC)、甘油三酯(TG)含量的影响。结果酒精灌胃6周后大鼠形成酒精性脂肪肝。与模型组比较,赶黄草提取物组及槲皮素组大鼠肝脏脂肪变明显改善,赶黄草及槲皮素组大鼠血中ALT,AST,TC,TG均明显降低(P<0.05,P<0.01);槲皮素组与含等量槲皮素的赶黄草提取物组比较,槲皮素组大鼠血中ALT,AST,TC,TG均明显高于赶黄草提取物组(P<0.05)。结论赶黄草和槲皮素均具有预防酒精性脂肪肝的作用,但赶黄草效果更好;除槲皮素外,在赶黄草中还可能存在其他具有预防酒精性脂肪肝的更重要化学成分,也可能存在与槲皮素起协同作用的预防酒精性脂肪肝的化学成分。

OBJECTIVE To compare alcoholic fatty liver prevention action of Penthorum chinese Pursh . and quercetin. METHODS Rat models of alcoholic fatty liver were induced by intragastric administration of alcohol and breeding provender with 1.5% FeSO4. Meanwhile, the rats were treated with tiopronin, quereetin and Penthorum chinese Pursh. extract. The histopathologieaI changes in the liver were determined. The serum levels of alanine aminotransferase （ALT）, aspartate transaminase （AST）, total cholesterol （TC） and triglyceride （TG） were determined. RESULTS Rat models of alcoholic fatty liver were induced successfully after 6 weeks intragastric administration of alcohol. Compared to the model group, the steatosis states of liver in the quercetin group and Penthorum chinese Pursh. extract group （P 〈 0. 05, P 〈 0. 01 ） were improved, while the serum ALT, AST, TC and TG levels decreased significantly. The serum ALT, AST, TC and TG levels in the quercetin group were higher than those in Penthorum chinese Pursh. extract group with the same quercetin content （ P 〈 0. 05 ）. CONCLUSION Both Penthorum chinese Pursh. and quercetin can prevent alcoholic fatty liver, but Penthorum chinese Pursh. does better than quercetin. The possible reason may be that other important chemical components besides quercetin in Penthorum chinese Pursh. have fatty liver prevention action, or there are chemical components which have synergetic effect with quercetin.