自噬与肿瘤

Autophagy and Tumor

自噬（autophagy）作为细胞一种基本生物学特征，具有独特的形态学改变和特有的调控通路。近年来，自噬在关于对肿瘤的作用的研究已成为热点，在不同的种类肿瘤中，自噬扮演着不同的角色，分为促进和抑制肿瘤两种作用。自噬异常与人类恶性肿瘤的发生、发展联系紧密，其启动及调节与细胞能量代谢、微环境变化、抑癌基因及癌基因家族及复杂的信号调节等有关。清楚了解自噬的特点可为肿瘤治疗提供新的方向。

As a basic biological characteristic of cells, autophagy corresponds with specific morphological changes and a specific regulating pathways. In recent years autophagy has become a hot topic, in part due to its roles in both promoting and preventing neoplasms. Irregularities in autophagy in humans are closely linked to the occurrence of malignant neoplasms. Activation and regulation of autophagy influence not only cellular metabolism, but also microenvironments, antioncogene and oncogene function as well as complex signaling pathways. A clear understanding of autophagy would provide new approaches to the treatment of neoplasms.