HLA-DRB1基因与慢性荨麻疹的相关性

Correlationship between HLA-DRB1 Alleles and Chonic Urticaria in Guangxi

目的探讨慢性荨麻疹与HLA-DRB1等位基因的相关性。方法采用聚合酶链反应-序列特异性引物方法,检测慢性荨麻疹(CU)患者组144例(汉族64例,壮族80例)和正常对照组199例(汉族95例,壮族104例)的HLA-DRB1等位基因频率,使用SPSS13.0统计软件分析。结果在检测的16个位点中,DRB1*12和*1401等位基因频率在汉族患者组与汉族对照组间差异有统计学意义(Pc<0.001,RR=6.715;Pc<0.001,RR=28.776);DRB1*1401等位基因频率在壮族患者组与壮族对照组间差异有统计学意义(Pc=0.002,RR=4.526)。DRB1*12等位基因频率在汉族患者组与壮族患者组间比较,差异有统计学意义(Pc<0.001)。结论 DRB1*12和*1401等位基因可能与汉族CU有相关性;DRB1*1401等位基因可能与壮族CU有相关性;DRB1基因多态性在汉、壮族间分布有差异。

Objective To investigate the genetic susceptibility of chronic urticaria. The corretationship between HLA- DRB1 alleles and chronic urticaria was evaluated. Methods PCR amplification with sequence-specific primers was used to detect HLA-DRB1 alleles in 144 chronic urticaria patients （64 cases of Han and 80 cases of Zhuang） ,the results were compared to those of 199 normal controls（95 cases of Han and 104 cases of Zhuang）. Results The diffences of frequency of＇ DRBI ＊ 12, ＊ 1401 alleles in the patient group and the control group in Han were statistically significant（Pc 〈0. 001 ,RR =6. 715 ;Pc 〈0. 001 ,RR =28. 776）. The difference of the frequency of DRBI ＊ 1401 allele in the patient group and the control group was statistically significant in Zhuang （Pc = 0. 002, RR = 4. 526）. The difference of the frequency of DRB1 ＊ 12 allele in Han and Zhuang patients was statistically significant（ Pc 〈 0. 001 ）. Conclusion DRB1 ＊ 12, ＊ 1401 alleles may be associated with chronic urticaria in Han people. DRBI ＊ 1401 allele may be associated with chronic urticaria in Zhuang people. There are discrepancy in the distribution of HLA-DRB1 alleles in Hart and Zhuang people.