银屑病患者食物不耐受IgG抗体检测

The Detection of Food-intolerance IgG Antibodies in Patient with Psoriasis

目的检测银屑病患者14种血清食物特异性IgG抗体水平。方法采用酶联免疫吸附法(ELISA)检测63例银屑病患者及60例健康对照者14种血清食物特异性IgG抗体水平。将银屑病组中58例IgG抗体检测阳性者,随机分成观察组和对照组(每组29例),观察组进行不耐受食物禁食/轮替调整6个月,然后再次检测两组IgG抗体水平。结果银屑病组食物不耐受检测阳性率为92.06%,健康对照组食物不耐受检测阳性率为16.67%,两组相比差异有统计学意义(P<0.05);食物特异性IgG阳性数与银屑病严重程度指标PASI评分呈正相关,rs=0.886,P<0.05,差异有统计学意义;观察组禁食/轮替调整6个月后IgG抗体水平与对照组相比明显下降,差异有统计学意义(P<0.05)。结论食物不耐受与银屑病之间具有相关性,饮食调整对本病的防治具有重要意义。

Objective To explore the level of 14 food-specific lgG antibodies in serum of psoriasic patient. Methods Enzyme linked immunosorbent assay（ELISA） was applied to detecting food intolerance-specific serum IgG antibody level in 63 patients with psoriasis and 60 healthy people. The 58 cases in psoriasis group with positive lgG antibody were randomly divided into observed group and control group（ each group n = 29）. The observed group were prevented from eating intolerant food and rotation adjustment for 6 months, and then their lgG antibody levels were detected again. Results The positive rate of food intolerance of psoriasis group was 92.06%, while the healthy control group was 16.67%, and the difference was significant （P 〈 0.05 ） ; The number of food-specific IgG-positive was positively correlated with the PASI score, and the difference was statistically significant ; After the patients were prevented from eating intolerant food and rotation adjustment for 6 months, the IgG antibody levels decreased significantly compared with the control group, and the difference were significant （ P 〈 0. 05 ）. Conclusions There was relationship between food-intolerance and psoriasis, and dietary modification were important to the prevention and treatment of psoriasis.