润燥止痒胶囊联合盐酸依匹斯汀胶囊治疗血虚风燥型慢性荨麻疹的疗效观察

The Clinical Study on Runzaozhiyang Capsule Combined with Epinastine Capsule in the Treatment of Chronic Urticaria with Blood Deficiency and Wind Dryness Syndrome

目的观察润燥止痒胶囊联合盐酸依匹斯汀胶囊治疗血虚风燥型慢性荨麻疹的临床疗效,探讨其对患者IgE,IL-4及IFN-γ客观性指标的影响。方法将85例血虚风燥型慢性荨麻疹患者随机分为中药组(28例)、西药组(27例)及中西医结合组(30例),观察其疗效及复发率。于治疗前及治疗后分别检测三组患者IgE,IL-4及IFN-γ水平。结果治疗14天及28天中药组、西药组、中西医结合组有效率分别为29.63%,77.78%和60.00%及84.00%,75.86%和96.55%。治疗14天,西药组与中西医结合组均明显优于中药组(P<0.05);治疗28天,中西医结合组明显优于中药组(P<0.05)。治疗结束后28天,中药组、西药组、中西医结合组复发率分别为33.33%,60.00%和31.57%,中药组与中西医结合组复发率均明显低于西药组(P<0.05)。药物不良反应发生率中药组、西药组、中西医结合组分别为21.43%,29.63%和10.00%,中西医结合组均明显优于中药组与西药组(P<0.05)。治疗28天,三组血清IgE,IL-4水平较治疗前明显下降(P<0.05),而IFN-γ明显升高(P<0.05)。结论润燥止痒胶囊联合盐酸依匹斯汀胶囊治疗血虚风燥型慢性荨麻疹可以提高治疗效果、降低复发率。

Objective To study the effects of Runzaozhiyang capsule combined with Epinastine capsule on chronic urticaria with blood deficiency and wind dryness syndrome and effects on the serum levels of immunoglobulin E （lgE）, interleukin-4（IL-4） and interferon-γ/（IFN-γ）. Methods A total of85 patienls with chronic urticaria with blood deficiency and wind dryness syndrome were randomly divided into 3 groups, TCM group, western medicine group and TCM combined with western medicine group. The serum levels of IgE, IL-4 and IFN-γ were detected before and after treatment by enzyme-linked immune sorbent assay（ELISA）. Results At treatment for 14 days and 28 days,the total effective rate were 29.63% and 77.78% ,60.00% and 84% , 75.86% and 96.55% respectively in the TCM group, western medicine group, and the TCM combined with western medicine group. At the 14th day, the effects in the TCM combined with western medicine group and the western medicine group were better than that in the TCM group （ P 〈 0.05 ）. At the 28th day, the effects in the TCM combined with western medicine group were better than that in the TCM group（ P 〈 0.05 ）. At the 28th day after treatment, the recurrence rate of well-healed cases in the TCM group, western medicine group, and TCM combined with western medicine group were 33.33% , 60% and 31.57% respectively. The recun^nce rate in the TCM group, the TCM group and the western medieine group were lower than that in the western medicine group. The side effect rate in the TCM group, western medicine group, and the TCM combined with western medicine group were 21.43% ,29.63% ,10% respectively. The side effect were lower in the TCM combined with western medicine group than in TCM group and the western medicine group（P 〈0.05）. Conclusion Runzaozhiyang capsule combined with Epinastine capsule was better than tablet Runzaozhiyang capsule in treatment of chronic urticaria with blood deficiency and wind thwness syndrome in the total effective rate, and the recurrence rate.