摘要
Interleukin-33 （IL-33）, a newly recognized IL-1 family member, is expressed by various tissues and cells. Since it can combine with chromosomes, IL-33 is regarded as an intracellular transcription repressor. Upon proinflammatory stimulation, it is released as an extracellular cytokine to function as an alarmin to dangerous signals. The IL-33 receptor is a heterodimer complex composed of ST2 and the IL-1 receptor accessory protein, the latter being conserved in other IL-1 family members. The IL-33/ST2 signaling pathway plays critical roles in inflammatory and immune diseases, as well as in central nervous system （CNS） diseases. Recently, there has been an increasing focus on IL-33, particularly on its production and functions in the CNS. The present review mainly focuses on progress in research on IL-33, especially its roles in the CNS.
白介素-33(interleukin-33,IL-33)是IL-1家族的新成员,在多种细胞和组织中表达。IL-33能与常染色体结合,因此被认为具有抑制核内转录的作用。当受到炎性刺激时,IL-33可作为危险信号的警报释放到细胞外发挥细胞因子的作用。IL-33的受体是由ST2和IL-1受体结合蛋白组成的异物二聚体,其中IL-1受体结合蛋白是所有白介素家族受体共有的部分。IL-33/ST2信号通路通过调节细胞因子的生成,不仅对炎症、免疫性疾病发挥关键作用,还参与了许多其他疾病如中枢神经系统疾病。近年来有关IL-33尤其是它在中枢神经系统中表达及功能的研究不断增多,本文对IL-33及其在中枢神经系统中的作用进行了综述。
基金
supported by the National Natural Science Foundation of China(No.31000495,30970975,30821002)
Research Fund for the Doctoral Program of Higher Education of China(No.20100071120046,20100071120042)
the Fundamental Research Funds for the Central Universities
Young Scientist Foundation of Fudan University,China
