用吸收边界方法研究驱动马达蛋白在不对称势中扩散寻找的等待时间分布

Studying Dwell-Time Distributions for Kinesin's Mechanical Steps in an Asymmetric Conformational Potential with the Absorbing-Boundary Method

本文在考虑驱动马达蛋白在机械化学循环中自身构象变化的基础上,采用有吸收边界条件的随机动力学模型,研究了驱动马达在不对称势中有偏的扩散寻找过程。我们得到驱动蛋白行走过程中向前与向后行走的几率比和所受负载力变化的规律,以及其向前与向后行走的等待时间分布和平均等待时间随负载力变化的趋势和图像。所得结论与Carter和Cross的实验数据所呈现的规律相符。另外还发现,平均等待时间及向前与向后行走的几率比敏感依赖于环境温度等因素。

Based on kinesin＇s conformational changes during the mechanochemical cycle,we present a stochastic dynamics model,in which kinesin undergoes a biased diffusive search in an asymmetric potential.Using absorbing boundary method,we have numerically studied dwell-time distributions and ratio of forward to backward steps in the presence of different load forces.And the results agree with Cross and Carter＇s experimental data.Also,we find out that the ratio of forward to backward steps sensitively depends on the temperature.