变应性鼻炎患者血清IL-21检测及意义

Measurement of serum IL-21 in patients with allergic rhinitis and its significance

目的探讨IL-21在变应性鼻炎患者血清中的含量及其与变应原特异性IgE水平的相关性。方法研究对象分为变应性鼻炎组(24例)和正常对照组(12例),分别采用ELISA法和ImmunoCAP 100全自动免疫荧光定量分析系统检测受试者血清中IL-21含量及常见吸入物变应原特异性IgE水平。结果变应性鼻炎组血清特异性IgE水平分别为2级9例、3级4例、4级8例、5级1例、6级2例;正常对照组血清特异性IgE水平均为0级。变应性鼻炎和正常对照组血清IL-21含量分别为(199±97.86)pg/mL和(7.58±5.49)pg/mL,差异无统计学意义(P>0.05)。变应性鼻炎患者血清IL-21含量与屋尘螨变应原特异性IgE水平无显著相关性(P>0.05)。结论 IL-21在变应性鼻炎的发病中可能无明显作用。

Objective To detect the serum IL-21 in patients with allergic rhinitis （AR） and its correlation with allergen-specific IgE levels. Method Subjects were divided into two groups： the AR group （n=24） and the healthy control group （n=12）. The serum levels of IL-21 and specific IgE for common inhalant allergens were determined by using the ELASA method and ImmunoCAP 100 system, respectively. Results Allergen-specific IgE levels in AR patients were categorized as grade 2 （9 cases）, grade 3 （4 cases）, grade 4 （8 cases）, grade 5 （1 case） and grade 6 （2 cases）, respectively. While in healthy controls they were all categorized as grade 0. The serum levels of IL- 21 was 199~97.86 pg/mL in AR patients and 7.58~5.49 pg/mL in healthy controls （P〉0.05）. Furthermore, no significant correlation was observed between the serum levels of IL-21 and specific IgE for house dust mite （P〉0.05）. Conclusion Our study suggested that IL-21 might be not involved in the pathogenesis of AR.