胆囊癌组织中p-STAT3、survivin的表达及意义

Significance and expression of p-STAT3 and survivin in primary gallbladder carcinoma

目的探讨胆囊癌中p-STAT3和survivin蛋白表达及其在胆囊癌发生、发展中的作用。方法采用免疫组织化学SP法检测45例胆囊癌组织、20例慢性胆囊炎组织中p-STAT3及survivin蛋白的表达，并分析其与临床病理特征、预后的关系。结果本组45例胆囊癌组织中p-STAT3和survivin蛋白阳性率分别为55．6％（25／45）、64．4％（29／45），明显高于慢性胆囊炎组织5．0％（1／20）、10％（2／20）（P〈0．01）。在胆囊癌组织中p-STAT3的表达与survivin表达呈正相关（r=0．830，P〈0．01）。p-STAT3和survivin蛋白的表达与胆囊癌病理组织分级、Nevin分期、有无淋巴结转移和3年生存率有关（P〈0．01，P〈0．05）。结论p-STAT3、survivin参与了胆囊癌的发生、发展，可能作为判断胆囊癌转移、预后的临床指标。

Objective To detect the expression of p-STAT3 and survivin in primary gallbladder carcinoma （PGC） and explore its significance for the genesis and development of PGC. Methods The expression of p-STAT3 and survivin were determined with immunohistochemistry in samples from 45 PGC tissues and 20 chronic eholecystitis. The relationship between the expression of these proteins and various elinicopathological factors was evaluated. Results The expression rate of p-STAT3 and survivin in 45 PGC tissues was 55.6% （ 25/45 ） and 64.4% （ 25/45 ） , respectively, which was significantly higher than those in 20 chronic cholecystitis tissues 5.0% （ 1/20 ） , 10% （ 2/20 ） （ P 〈 0. 01 ）. pSTAT3 expression was correlated with survivin （ r = 0. 830, P 〈 0. 01 ）. p-STAT3 and survivin protein expression were significantly associated with histopathological grading, lymph node metastatis, nevin staging and 3-year survival rate. Conclusions p-STAT3 and survivin might play a vital role in the development of PGC. The expression of p-STAT3 or survivin was an independent prognostic factor in PGC.