自拟温肾逍遥汤治疗围绝经期干眼症的疗效观察

Clinical observation of Warming Kidney Xiaoyao Decoction on perimenopausal dry eye syndrome

目的探讨自拟温肾逍遥汤治疗围绝经期干眼症患者的临床疗效。方法收集高健生主任医师2009年2月至2010年4月门诊治疗的围绝经期干眼症患者31例(56只眼),予口服温肾逍遥汤5周,局部不用药物。分别记录治疗前和治疗5周患者的自觉症状积分、泪膜破裂时间(breakup time of tear film,BUT)、泪液分泌试验(Schirmer I test,SIt)数值。结果 56只眼中44只眼(23例)治愈(78.57%);5只眼(3例)好转(8.93%);7只眼(5例)全身症状改善,眼部症状改善不明显(12.50%),总有效率为87.50%。服药后患者自觉症状积分减少,BUT、SIt值增加,治疗前后各指标比较差异均有统计学意义(P<0.05)。结论温肾逍遥汤不仅能够明显改善围绝经期女性的干眼症自觉症状,还可以明显改善患者的泪液分泌,延长泪膜破裂时间,具有良好的临床疗效。

OBJECTIVE To explore the clinical effect of Warming Kidney Xiaoyao Decoction（WKXD） for perimenopausal dry eye syndrome.METHODS In the retrospective clinic trial,31 perimenopausal women（56 eyes） with dry eye symptoms were treated with WKXD between February 2009 and April 2010.Subjective symptom scores,tear film break-up time and Schirmer I test scores were recorded before treatment and 5 weeks after treatment respectively,which were analysed by paired t-test.RESULTS After treatment,44 out of 56 eyes（78.57%） were cured;5 out of 56 eyes（8.93%） were improved;7 out of 56 eyes were not improved on eye symptoms but were improved on systemic symptoms.The effective rate was 87.5% on eye symptoms and 100% on the systemic symptoms.The statistical analysis showed significant difference between before treatment and treatment after 5 weeks on subjective symptom scores,tear film break-up time and Schirmer I test scores.CONCLUSIONS Warming Kidney Xiaoyao Decoction was effective in treating dry eye symptoms of perimenopausal women.