功能性垂体腺瘤伽玛刀治疗

Gamma knife treatment for secretory pituitary adenoma

目的探讨伽玛刀治疗功能性垂体腺瘤的效果并分析影响疗效的相关因素。方法回顾性分析我中心2006年1月-2010年4月伽玛刀治疗的获得完全随访的112例功能性垂体腺瘤患者的临床资料。以50%的等剂量曲线包绕靶区,给予边缘剂量10-25 GY,巨大腺瘤采用分次治疗。根据术后临床症状、肿瘤大小及激素水平评价疗效。结果随访12-64个月,平均30.5个月,其中临床症状缓解率为82.1%,肿瘤大小控制率为89.3%,激素水平控制率70.5%,3例出现垂体功能低下（2.6%）,且伽玛刀治疗垂体腺瘤的疗效与肿瘤大小、边缘剂量、侵袭性有关。结论伽玛刀治疗功能性垂体腺瘤安全有效的方法,其疗效与肿瘤大小、侵袭性,边缘剂量有关。

Objective The aim of the study was to investigate the efficacy and analyze the factors associated in secreting pituitary adenomas after gamma knife.Methods Between January 2006 and April 2010,112 patients with a secretory pituitary adenoma treated by gamma knife in our center were studied.50% isodose curve enveloping the target,the prescript radiation dosage was 10-25 Gy,The huge adenoma using fractionated treatment,the efficacy was evaluate by the control of tumor growth and hormonal,and the clinical symptoms alleviation.Results The median follow-up was 30.5 months（12-64 months）.Tumor growth was controlled in 90.4%,and hormonal control in 76.5%,the clinical symptoms alleviation in 82.1%.In 3（2.6%） patients there was pituitary insufficiency.and the efficacy of gamma knife treatment for secretory pituitary adenoma is related with tumor size,invasive and marginal dose.Conclusion Gamma knife radiosurgery for secretory pituitary adenomas are safe and effective method,it＇s efficacy is relevant with tumor size invasive and marginal dose.