包裹性腹膜硬化症

Encapsulating peritoneal sclerosis

包裹性腹膜硬化症(EPS)是腹膜透析晚期常见并发症之一,发生率和死亡率均较高,其发生机制尚不明确,可能与上皮细胞向间充质转化及介导纤维化和血管增生的细胞因子有关。高糖、非生理相容性透析液、腹膜炎、尿毒症毒素均能促进其发生发展。深入探讨EPS的发生机制,并采取针对性的手段,是预防和治疗EPS的关键。

The encapsulating peritoneal sclerosis （EPS） is a common complication of long-term peritoneal dialysis （PD）, and carries significant morbidity and mortality. Although EPS is strongly associated with the duration of PD, the pathogenesis remains only partly understood. The peritoneal membrane sclerosis resulted from epithelial to mesenchymal transition and the molecular mediators of fibrosis and angiogenesis. The highglucose exposure, nonphysiological dialysis fluids, peritonitis, and uremia may be responsible for these changes.