银屑病的生物治疗研究进展

Research Advances in the Biological Therapies for Psoriasis

近年来,随着在银屑病发病机制研究上取得的实质性进展,尤其是对分子免疫学基础的认识不断深入,出现了一系列新的靶向干预制剂———新型生物制剂。它们主要分为两类:抗细胞因子治疗和抗T细胞治疗,且主要用于治疗中-重度银屑病及银屑病型关节炎患者。虽然,生物制剂的短期疗效尚令人满意,但它们的长期疗效和安全性还有待进一步研究,以便更好地指导临床医师合理用药。

Substantial advances being made in the pathogenesis of psoriasis these years,especially in the molecular and immunologic basis,had led to new agents that target these specific steps.This review was intend to introduce the new therapeutic approach that was mainly classified as T cell inhibitors and anti-cytokine agents in the management of moderate-to-severe psoriasis and psoriatic arthritis.Besides the satisfied short-term efficacy,the long-term efficacy and safety of these agents should be further studied to improve rational administration for the dermatologists.