间隙性连接蛋白37 C1019T基因多态性与冠心病相关性研究进展

Research Progress of Correlation between Connexin37 C1019T Gene Polymorphism and Coronary Heart Disease

冠状动脉粥样硬化性心脏病是严重危害人类健康的常见疾病,是一种多因素、多基因疾病。遗传流行病学研究显示遗传因素在冠状动脉粥样硬化性心脏病的发生、发展中有重要意义。近年来随着分子生物学技术的迅速发展,从基因方面阐明冠状动脉粥样硬化性心脏病的发生将为冠状动脉粥样硬化性心脏病的诊治开辟一个新领域。在此对其中的一种候选基因即间隙性连接蛋白37C1019T基因多态性与冠状动脉粥样硬化性心脏病的相关性研究进行综述。

Coronary atherosclerasis heart disease（CAHD）is a common disease that seriously harms mankind′s health,which is a multifactorial and polygenic disorder.Research in genetic epidemiology demonstrates that genetic factors are significant in the occurrence and development of CAHD.With the rapid development of molecular biological techniques,interpreting the genetic etiological factors of coronary artery disease will create a new way of both diagnosis and treatment of CAHD.Here is to discusses the progress of the association between the polymorphism of connexin 37 gene,which is one of the candidate genes,and CAHD.