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microRNA在心律失常中作用的研究进展

Research Advances in the Roles of microRNA in Arrhythmia
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摘要 microRNA(miRNA)是一类内源性的非编码RNA分子,能调节转录后靶基因的表达,在机体的生长发育、细胞增殖、代谢和凋亡等生理过程中发挥着重要的作用。miRNA在体内的水平变化与心律失常、心肌梗死、心力衰竭等心脏疾病的形成密切相关,尤其是可以通过影响细胞膜离子通道的表达而引起心律失常。 microRNA（miRNA）are a class of endogenous non-coding RNA,which participate in regulating gene expression at post-transcriptional level.miRNA play important roles in the physiological processes of cell growth,cell proliferation,metabolism,and apoptosis.The changes of miRNA levels are also closely related to the formation of cardiac diseases,including arrhythmia,myocardial infarction,heart failure and so on,especially that they can cause arrhythmia by affecting the expression of cell membrane ion channels.
作者 赵沿祥 刘芳 王营
机构地区 山东中医药大学 山东中医药大学第二附属医院心脏中心
出处 《医学综述》 2011年第21期3228-3230,共3页 Medical Recapitulate
关键词 MICRORNA 离子通道 心律失常 microRNA Ion channel Arrhythmia
分类号 R541.7 [医药卫生—心血管疾病]
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参考文献28

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二级参考文献8

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医学综述
2011年 第21期

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