紫杉醇在头颈肿瘤的放疗增敏作用研究进展

Researh Progress of Sensitization Effect of Paclitaxel in Head and Neck Cancer Radiotherapy

头颈部恶性肿瘤的治疗是一个复杂而又棘手的问题,放射治疗是治疗头颈部恶性肿瘤的重要手段之一。然而,单纯的放疗仅对辐射敏感的部分肿瘤有比较好的疗效,大部分肿瘤对辐射并不敏感。紫杉醇作为一种广谱的抗肿瘤药物,具有独特的抗肿瘤作用机制,并且临床上紫杉醇的放疗增敏作用已经得到认可,为头颈肿瘤的治疗提供了新的手段。

Head and neck malignant tumor treatment is a complex and difficult problem,radiation therapy is one of the important treatments for the disease.However,radiotherapy alone has a relatively good therapeutic effect to some tumors sensitive to radiation,while most tumors are insensitive.Paclitaxel is broad-spectrum antitumor drugs,and it has a unique anti-tumor mechanism.Clinically paclitaxel radiotherapy sensitization effect has already been confirmed,which provides a new approach for the treatment of head and neck cancer.