尖锐湿疣患者外周血单一核细胞中干扰素调节因子7和Toll样受体9mRNA的表达

Expressions of interferon regulatory factor 7 and Toll-like receptor 9 in peripheral blood mononuclear cells （PBMCs） of patients with condyioma acuminatum

目的探讨干扰素调节因子7、Toll样受体9在尖锐湿疣发病中的作用及临床意义。方法采用逆转录聚合酶链反应检测25例尖锐湿疣患者外周血单一核细胞中干扰素调节因子7、Toll样受体9mRNA的水平，20例正常人作对照。结果尖锐湿疣患者外周血单一核细胞中干扰素调节因子7与Toll样受体9mRNA表达水平均明显高于正常对照组，差异有统计学意义（P值均〈0．01）。结论尖锐湿疣患者外周血中干扰素调节因子7、Toll样受体9表达升高。

Objective To investigate the role and clinical significance of interferon regulatory factor 7 （IRF7） and Toll-like receptor 9 （TLR9） in the development of eondyloma aeuminatum （CA）. Methods Reverse transcription-PCR was performed to analyze the mRNA expressions of IRF7 and TLR9 in peripheral blood mononuclear cells （PBMCs） of 25 patients with CA and 20 normal human controls. Results The expression levels of IRF7 and TLR9 mRNA in PBMCs were significantly higher in the patients with CA than in the controls （both P 〈 0.01 ）. Conclusion There is a significant increase in the expression of IRF7 and TLR9 in the PBMCs of patients with CA.