局部注射少量A型肉毒毒素治疗上半面部皱纹的临床研究

Clinical studies of small amount of botulinum toxin type a local injection in patients with upper facial wrinkles

目的:观察局部注射少量A型肉毒毒素(BTXA)去除上半面部皱纹的临床疗效。方法:应用A型肉毒毒素的198例患者,其中眉间纹65例,鱼尾纹80例,额纹20例,鼻背部皱纹33例。所有患者行局部多点注射A型肉毒毒素,浓度为4U/0.1ml,并根据不同的患者调整剂量和浓度。记录患者疗效、维持时间与不良反应。结果:A型肉毒毒素治疗面部上三分之一皱纹有效率为100%,显效率94.4%。肌肉麻痹的效果通常持续3～6个月不等,不良反应主要为4例上睑下垂,3例局部水肿和4例青紫,各占2.0%、1.5%和2.0%。上述症状于3～10内自行完全消失。结论:A型肉毒毒素局部注射治疗面部上三分之一皱纹起效迅速、无创伤、简便易行。

Objective To observe the clinical effect of small amount of botulinum toxin type A（BTXA） local injection to remove half of the clinical effect of facial wrinkles.Methods 198 botulinum toxin type A patients,including 65 cases of frown lines,80 cases of crow＇s feet,20 cases of the wrinkles on the forehead,33 cases of wrinkles of nasal back.All patients underwent local multi-point injection of botulinum toxin type A,the concentration is 4U/0.1ml,and adjusted the dose according to different patient and concentration.We recorded the outcomes,effective duration and adverse reactions.Results The effective rate of botulinum toxin type A in treatment with facial wrinkles was 100%,the obvious rate was 94.4%,and the effective duration lasts 3～6 months.The adverse effects of treatment were four cases of ptosis,3 and 4 cases with local edema and bruising,taking account 2.0%,1.5% and 2.0%,respectively.The symptoms disappeared on their own way.Conclusion A local injection of botulinum toxin type A treatment of upper a third facial wrinkles was rapid onset,non-invasive,non-traumatic and simple.