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脑胶质瘤干细胞研究进展 被引量:2

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摘要 脑胶质瘤是常见的脑原发恶性肿瘤,其治疗主要依据WHO分级;手术切除为首选,术后放疗及放化疗是提高脑胶质瘤生存期的重要手段。低分级脑胶质瘤的治疗效果较好,生存期较长;而高分级患者治疗后的生存期只能以月来描述。脑胶质瘤治疗失败的主要原因是局部复发,而导致复发的重要原因是胶质瘤干细胞未得到有效控制。因此,脑胶质瘤干细胞的鉴别及生物学特性的研究成为近年来国内外学者关注的热点,笔者综述脑胶质瘤干细胞的研究进展。
作者 盖雪 杨伟志
出处 《中华放射肿瘤学杂志》 CSCD 北大核心 2011年第6期493-496,共4页 Chinese Journal of Radiation Oncology
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  • 1Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med, 2005, 352( 10) :987-996.
  • 2Cheng L, Bao S, Rich IN. Potential therapeutic implications of cancer stem cells in glioblastoma. Biochem Pharmacol, 2010, 80 (5) :654-665.
  • 3Dirks PB. Brain tumor stem cells: the cancer stem cell hypothesis (trit large. Mol Oncol, 2010, 4 (5) :420-430.
  • 4Mannino M, Chalmers AJ. Radioresistance of glioma stem cells: intrinsic characteristic or property of the 'microenvironment-stem cell unit' Mol Oncol, 2011 , 5 (4) :374-386.
  • 5Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature, 2006, 444 (7120) :756-760.
  • 6Tamura K, Aoyagi M, Wakimoto H, et al. Accumulation of CD133 -positive glioma cells after high-dose irradiation by Gamma Knife surgery plus external beam radiation. J Neurosurg, 2010, 113 ( 2) : 310 -318.
  • 7Ropolo M, Daga A, Griffero F, et a1. Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. Mol Cancer Res, 2009,7(3) :383-392.
  • 8Molofsky AV, Pardal R, Morrison SJ. Diverse mechanisms regulate stem cell self-renewal. CUIT Opin Cell BioI, 2004, 16 (6) :700-707.
  • 9Facchino S, Abdouh M, Chatoo W, et al. BMIJ confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery. J Neurosci, 2010,30 (30) : 10096-10111.
  • 10Wang J, Wakeman TP, Lathia .. JD, et al. Notch promotes radioresistance of glioma stem cells. Stem Cells, 2010, 28 ( 1 ) : 17 -28.

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