唾液酸苷酶法检测在细菌性阴道病诊断中的意义

The significance of neuraminidase assay in the diagnosis of bacterial vaginosis

目的探讨唾液酸苷酶法检测对诊断细菌性阴道病(BV)的意义。方法应用唾液酸苷酶法快速检测266例BV(A组)、470例健康妇女(B组)、172例真菌性阴道炎患者(C组)和92例滴虫性阴道炎患者(D组)。结果 A组阳性率93.61%(249/266),明显高于B组的3.62%(17/470)、C组的3.49%(6/172)和D组的9.78%(9/92)(P<0.01)。阴道唾液酸苷酶预测细菌性阴道病的敏感性为93.61%(249/266),特异性为96.38%(453/470)。结论采用唾液酸苷酶法诊断BV具有特异性强、设备简单、操作简便、快速等优点。

Objective To investigate the clinical significance of sialic acid enzymatic assay in the diagnosis of bacterial vaginosis（BV）.Methods The sialic acid enzymatic assay was used to measure BV rapidly in 266 patients with BV（group A）,470 healthy women as the controls（group B）,172 cases with fungal vaginitis（group C）,and 92 cases with trichomonas vaginitis（group D）.Results The positive rate of sialic acid enzymatic test in group A was 93.61%（249/266）,which was significantly higher than 3.62%（17/470） in group B,3.49%（6/172）in group C and 9.78%（9/92） in group D（P〈0.01）.The sensitivity and specificity of vaginal sialidase activity for predicting BV were 93.61%（249/266） and 96.38%（453/470）,respectively.Conclusion Measuring vaginal sialidase has a high specificity in the diagnosis of BV with the advantages of simple instruments,easy performance and quick report.