CXCR4和VEGF-C在胃癌中的表达及与临床病理因素的关系

Relationship Between Expression of CXCR4 and VEGF-C in Gastric Cancer and Several Clinicopathological Factors

目的通过检测趋化因子受体4(CXCR4)和血管内皮生长因子C(VEGF-C)在人胃癌组织中的表达,探讨其与胃癌临床病理因素的关系。方法应用免疫组织化学方法,检测CXCR4和VEGF-C在人胃癌组织中的表达,同时对其与胃癌临床病理因素的关系进行统计学分析。结果 CXCR4在胃癌组织中的阳性表达率为62%,其中无淋巴结转移组表达率为25%,淋巴结转移组表达率为73.68%,差异非常显著(P<0.01);无腹膜转移组表达率为(52.5%),显著低于腹膜转移组(100%)。VEGF-C在胃癌组织中的阳性表达率为72%。而且,CXCR4阳性表达与VEGF-C阳性表达呈显著正相关(К=0.597,P<0.01)。胃癌CXCR4和VEGF-C的表达水平与肿瘤的组织分化程度、肿瘤浸润深度、淋巴结转移及TNM分期密切相关(P<0.05)。结论 CXCR4和VEGF-C有望成为胃癌分子诊断和病期评估的标志之一。

Objective To investigate the relationship between expression of CXCR4 and VEGF - C in gastric cancer and several clinicopathological factors. Methods The expressions of CXCR4 and VEGF - C in 50 samples of human gastric cancer were detected by immuohistochemistry. The relationship between CXCR4 and VEGF - C expressions and the clinieopathologieal factors was statistically analyzed. Results The total positive rate of CXCR4 expression in these samples was 62% , and it was higher in the cases with lymphnode metastasis than that without lymphnode metastasis（73.68% vs 25% , P 〈 0.01 ）. And it was higher in the cases with peritoneal metastasis than that without peritoneal metastasis（ 100% vs 52.5% ,P 〈 0.01 ）. Meanwhile ,the total positive rate of VEGF - C expression was 72%. The positive expression of CXCR4 was consistent with the positive expression of VEGF - C （ K = 0. 597, P 〈 0.01 ） , and the expression levels of CXCR4 and VEGF- C were closely correlated with histological cellular differentiation, invasion depth, lymph node metastasis and TNM stage（ P 〈 0.05 ）. Conclusion CXCR4 and VEGF - C expressions may provide an evidence for molecular diagnosis and stage evalu- ation of gastric cancer.