安慰剂镇痛及内在机制

Placebo analgesia and its underlying mechanisms

安慰剂镇痛效应在常规临床实践中有着非常重要的作用和意义。有意识的预期过程及无意识的条件反射均能产生安慰剂镇痛效应,并影响相应的生理功能。安慰剂镇痛效应可以分为阿片和非阿片成分,这两类安慰剂镇痛效应可能涉及不同的通道、脑区及相关大脑回路。本文综述了产生安慰剂镇痛的机制及神经生理学研究进展,并提出今后的研究方向。

Placebo effect is a biological phenomenon with psychosocial-induced biochemical changes in a patient＇s brain and body.The term placebo-related effects aims to extend the concept of placebo effect to related phenomena and makes the underlying mechanisms better understood.The placebo analgesia effect is induced by different mechanisms,including the expectation of pain relief and conditioning.According to pharmacological studies,placebo analgesia is subdivided into opioid and non-opioid components while functional imaging data has also revealed brain regions and brain network involved in placebo analgesia.On the basis of previous research,this paper discussed the definition and underlying mechanisms of placebo analgesia,and gave some suggestions about related study in future.