注射用灯盏花素治疗血管性痴呆34例

Observation of Brevoscapine for injection on the treatment of vascular dementia

目的观察注射用灯盏花素治疗血管性痴呆的临床疗效。方法将68例血管性痴呆患者随机分为2组,治疗组34例,注射用灯盏花素50 mg加入5%葡萄糖注射液或0.9%氯化钠注射液250 mL,每日1次静脉滴注。对照组34例,用吡拉西坦氯化钠注射液8 g加入5%葡萄糖注射液或0.9%氯化钠注射液250 mL,每日1次静脉滴注。2组均治疗2周后停药1周,5周为1个疗程。观察2组治疗前后智力障碍程度、肢体功能及中医证候疗效的变化。结果 2组治疗后,智力障碍程度和肢体功能变化比较差异有统计学意义(P<0.05),治疗组优于对照组。结论注射用灯盏花素治疗血管性痴呆患者有效好的疗效。

Objective To observe the therapeutic effect of Brevoscapine for injection on the treatment of vascular dementia.Methods 68 patients with vascular dementia were randomly divided into two groups.34 patients in treatment group were treated by Breviscapine injection 50 mg in 5% glucose injection or 0.9% sodium chloride injection 250 mL,once intravenously a day.34 patients in control group were treated with piracetam injection 8 g of 5% glucose injection or 0.9% sodium chloride injection 250 mL,once intravenously a day.Two groups were treated for two weeks after discontinuation of a week,5 weeks for a course of treatment.The changes of dysgnosia degree,limb function and syndrome of traditional Chinese medicine before and after treatment were observed in two groups.Results There were significant differences between two groups in the degree of mental retardation and physical function after treatment（P0.05）,those in the treatment group were better than those in the control group.Conclusion Brevoscapine for injection has a good effect on the treatment of vascular dementia.