RhoC和IQGAP1蛋白在原发性肝细胞癌中的表达及意义

Significance of RhoC and IQGAP1 expression in hepatocellular carcinoma

目的:探讨RhoC和IQGAP1蛋白在原发性肝细胞癌(hepatocellular carcinoma,HCC)组织中的表达及其临床病理意义.方法:采用免疫组织化学法分别检测56例原发性肝细胞癌和15例正常肝组织中RhoC及IQGAP1蛋白的表达,并分析两者的相关性及与临床病理因素的关系.结果:RhoC和IQGAP1在原发性肝细胞癌组织中的表达明显高于正常组织(66%vs20%;75%vs13%,均P<0.05),且两者的表达呈正相关(r=0.631,P<0.05),并与肿瘤组织的分化程度及门脉浸润等均密切相关(均P<0.05).结论:RhoC及IQGAP1在原发性肝细胞癌的发生、发展中发挥重要的促进作用,可考虑作为HCC临床评价肿瘤生物学行为及评估预后的指标.

AIM： To detect the expression of RhoC and IQGAP1 proteins in hepatocellular carcinoma （HCC） and to analyze their clinicopathological significance. METHODS： The expression of RhoC and IQGAP1 proteins was detected by immunohistochemistry in 56 HCC specimens and 15 normal liver specimens. The association of RhoC and IQGAP1 protein expression with clinicopathologicalparamters was analyzed. RESULTS： The positive rates of RhoC and IQGAP1 expression were significantly higher in HCC than in normal liver tissue （66% vs 20%; 75% vs 13%, both P 〈 0.05）. The expression of RhoC and IQGAP1 proteins was related to tumor differentiation and invasion in HCC （both P 〈 0.05）. A positive correlation was noted between the expression of RhoC and that of IQGAP1 in HCC（r = 0.631, P 〈 0.05）.CONCLUSION： RhoC and IQGAP1 play significant roles in promoting the progression of HCC. Expression of RhoC and IQGAP1 can be used as useful parameters for clinical assessment of biological behavior and prognosis of HCC,