4Global initiative for asthma. Global Strategy For Asthma Management And Prevention[ S]. America, 2011 : 1-124.
5Spears M, Donnelly I, Jolly L, et al. Effect of low-dose theophylline plus beclomethasone on lung function in smokers with asthma: a pilotstudy[J]. Eur Respir J, 2009, 33(5) : 1010-1017.
6Hatzeimann A, Morcillo EJ, Lungarella G, et al. The preclinical pharmacology of roflumilast-a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease [J]. Pulm Pharmaeol Ther, 2010, 23(4) : 235-256.
7Barnes N, Pavord I, Chuchalin A, et al. A randomized, doubleblind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma [ J ]. Clin Exp Allergy, 2012, 42 ( 1 ) : 38-48.
8Pettipher R, Hunter MG, Perkins CM, et al. Heightened response of eosinophilie asthmatic patients to the CRTH2 antagonist 0C000459. Allergy[J]. 2014, 69(9) : 1223-1232.
9Singh D, Cadden P, Hunter M, et al. Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459 [J]. EurRespirJ, 2013, 41(1): 46-52.
10Slager RE, Otulana BA, Hawkins GA, et al. IL4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti- IL4 receptor alpha antagonist [ J]. J Allergy Clin Immunol, 2012, 130(2) : 516-522.