以NgR为靶点治疗脊髓损伤的研究进展
摘要
目前对脊髓损伤（spinal cord injury，SCI）的治疗方式有细胞移植、化学药物、基因治疗、针刺等。由于在SCI过程中，常伴有少突胶质细胞受损后释放的Nogo—A、髓鞘相关蛋白（MAG）、少突胶质细胞相关髓鞘糖蛋白（OMgp）三种髓鞘相关抑制分子，它们可以与Nogo-66受体（NgR）结合而抑制轴突再生。
出处
《中国脊柱脊髓杂志》
CAS
CSCD
北大核心
2011年第11期955-957,共3页
Chinese Journal of Spine and Spinal Cord
参考文献29
-
1Ruff CA,Wilcox JT,Fehlings MG. Cell-based transplantation strategies to promote plasticity following spinal cord injury[J], Exp Neurol,2011 ,[Epub ahead of print].
-
2Paterrfiti I,Mazzon E,Gil C,et al. PDE 7 inhibitors:new po- tential drugs for the therapy of spinal cord injury[J].PLOS One,2011,6( 1 ) :e15937.
-
3Bo X,Wu D,Yeh J,et al.Gene therapy approaches for neuro- protection and axonal regeneration ~ter spinal cord anti spinal root injury[J].Curr Gene Ther,2011,11 (2) : 101-115.
-
4Choi DC,Lee JY,Moon YJ,et al. Acupuncture-mediated inhi- bition of inflannnation facilitates significant tunctional recovery after spinal cord injury[J].Neurobiol Dis,2010,39 (3) : 272-282.
-
5Willerth SM,Sakiyama-Elbert SE. Cell therapy for spinal cord regeneration[J].Adv Drug Deliv Rev, 2008,60 (2) : 263-276.
-
6Li S,Liu BP,Budel S,et al. Blockade of Nogo-66,myelin-as- soeiated glyeoprotein,and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor recovery after spinal injury[J].J 10520. promotes axona] sprouting and Neurosci, 2004,24 (46) : 10511 -.
-
7Yu P,Huang L,Zou J, et al. Immunization with recombinant Nogo-66 receptor (NgR) promotes axonal regeneration and recovery of function after spinal cord injury in rats[J].Neurobiol Dis, 2008,32 (3) : 535-542.
-
8Yu P,Huang L,Zou J, et al. DNA vaccine against NgR pro- motes functional recovery after spinal cord injury in adult rats [J].Brain Res, 2007,1147 ( 1 ) : 66-76.
-
9Fournier AE, GrandPre T, Strittmatter SM. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration [J].Nature, 2001,409 ( 6818 ) : 341-346.
-
10Wang KC,Kopriviea V,Kim JA,et ahOligodendroeyte-myelin glyeoprotein is a Nogo receptor ligand that inhibits neurite outgrowth[J]. Nature, 2002,417 ( 6892 ) : 941-944.
-
1何希雨.以神经为靶点,治疗心脏病[J].心血管病防治知识,2010(2):67-67.
-
2张晓峰,朱起之,童俊容,黄云.药物致急性肾功能衰竭9例[J].华南国防医学杂志,2000,14(3):41-42.
-
3谢国明,李海霞,谢和平.化学药物治疗肺癌合并上腔静脉综合征[J].临床医学,2000,20(5):60-60. 被引量：1
-
4郑家驹.炎症性肠病－从多靶点走向特异性单靶点治疗[J].中华消化杂志,2008,28(12):793-794. 被引量：7
-
5宫红梅,张莲群.射频热凝靶点治疗椎间盘突出症73例围术期护理[J].齐鲁护理杂志（下半月刊）（外科护理）,2009,15(5):109-110.
-
6王超,韩娟,杨镇.核转录因子-κB在血管病变中的作用[J].临床外科杂志,2006,14(5):323-324.
-
7沈红,徐丽云,叶华茂.药物致急性肾衰竭92例临床分析[J].中国中西医结合肾病杂志,2006,7(9):545-546. 被引量：2
-
8完颜萍萍(综述),王俭勤(审校).糖尿病肾病发生发展机制的研究进展[J].国际泌尿系统杂志,2012,32(6):860-864. 被引量：2
-
9董立平,刘林,黄明斌,孟华鹏.经皮激光靶点治疗腰椎间盘突出症[J].临床外科杂志,2014,22(2):143-144.
-
10范茂龙.射频热凝靶点治疗腰椎间盘突出症40例[J].中华全科医学,2008,6(11):1173-1173. 被引量：3
