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单病例随机对照试验研究现状 被引量:3

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摘要 1 单病例随机对照试验简介 单病例随机对照试验,英文名称有randomized controlled trial in individual patient, single case experiment, N-of-1 trial, N-of-1 RCT和N-of-1 study等, 其中N-of-1 trial最为常用.单病例随机对照试验以患者自身作为对照,根据疾病特点设置3轮或以上试验,每轮治疗期和对照期时长由疗程决定,其顺序由第三方研究人员随机分配,保证受试者、研究者及结果测量者对分配情况均不知情,在治疗期和对照期研究者严格按照随机分配顺序给予干预措施或另一种干预措施(或安慰剂),每期结束后设置洗脱期来消除此干预措施的残余影响,对结果统计分析,评价干预措施疗效,以指导多个个体患者的医疗或护理[1].
出处 《中国循证儿科杂志》 CSCD 2011年第6期453-455,共3页 Chinese Journal of Evidence Based Pediatrics
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  • 1李平,刘保延,文天才,王映辉,高颖,徐浩,倪青,胡镜清,梁志伟,张华,姜兆顺,文川,李少文,李建红,郑建营.中医临床个体诊疗信息采集平台的建立与中医学理论知识的重组[J].中国中医药信息杂志,2005,12(4):7-7. 被引量:26
  • 2苗阳,徐浩,高铸烨.从《伤寒论》辨证组方看个体化诊疗[J].北京中医,2005,24(2):89-90. 被引量:4
  • 3许卫华.单病例随机对照试验在中医药临床研究中的应用与思考[J].中国临床药理学与治疗学,2005,10(11):1315-1317. 被引量:12
  • 4蔡德英.中医个体化医疗的现代研究基础[J].中国中医基础医学杂志,2006,12(2):143-144. 被引量:10
  • 5Guyatt G H, Keller J L, Jaeschke R, et al. The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience[J]. Ann Intern Med, 1990, 112 (4) :293-299.
  • 6Duchateau L,Pignon JP,Bijnens L,et al.Individual Patient-versus Literature-Based Meta-analysis of Survival Data:Time to Event and Event Rate at a Particular Time Can Make a Difference,an Example Based on Head and Neck Cancer.Control Clin Trials,2001,22(5):538-547.
  • 7Stewart LA,Parmar MK.Meta-analysis of the literature or of individual patient data:is there a difference? Lancet,1993,341(8842):418-422.
  • 8Clarke M,Stewart L,Parmar M.Benefits of meta-analysis using individual patient data.in Cochrane Colloquium.1995.Olso.
  • 9Neoadjuvant Chemotherapy for Cervical Cancer Meta-Analysis Collaboration (NACCCMA) Collaboration.Neoadjuvant chemotherapy for locally advanced cervix cancer.Cochrane Database Syst Rev,2004,(2):CD001774.
  • 10Gray R,Clarke M,Collins R,et al.The EBCTCG Overview of Adjuvant Therapy of Breast Cancer.Annals of the New York Academy of Sciences,698(1):339-348.

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  • 1刘建平.单个病例随机对照试验的设计与应用[J].中国中西医结合杂志,2005,25(3):252-254. 被引量:23
  • 2李先涛,梁伟雄,张伯礼.简单介绍成组序贯设计在临床试验中的应用[J].中国临床药理学与治疗学,2006,11(12):1433-1436. 被引量:7
  • 3Agency for Healthcare Research and Quality. Methods guide for effectiveness and comparative effectiveness re- views[M/OL]. Rockville, MD: AHRQ Publication No. 10 (12)-EHC063-EF, April 2012. Chapters are available at www.effectivehealthcare.ahrq.gov.
  • 4Guyatt G, Sackett D, Taylor D W, et al. Determining opti- mal therapy-randomized trials in individual patients[J]. N Engl J Med, 1986, 314(14): 889-892.
  • 5Guyatt G H, Haynes R B, Jaeschke R Z, et al. Users' guides to the medical literature XXV evidence-based med- icine: principles for applying the users' guides to patientcare[J]. Evidence-Based Medicine Working Group. JAMA, 2000, 284(10): 1290-1296.
  • 6Zucker D R, Deo A, Schmid C H. Dialysis research and N- of- 1 trials: made for each other?[J]. American Journal of Kidney Diseases, 2010, 55(4): 635-638.
  • 7Johnston B C, Mills E. N-of-1 randomized controlled trials: an oppommity for complementary and alternative medicine evaluation[J]. J Altern Complement Med, 2004, 10(6): 979-984.
  • 8Nikles J, Mitchell G K, Clavarino A, et al. Stakeholders' views on the routine use of N-of-1 trials to improve clini- cal care and to make resource allocation decisions for drug use[J]. Aust Health Rev, 2010, 34(1): 131-136.
  • 9Scuffham P A, Nikles J, Mitchell G K, et al. Using N-of-1 trials to improve patient management and save costs[J]. J Gen Intern Med, 2010, 25(9): 906-913.
  • 10Guyatt G. N of 1 randomized trials: a commentary[J]. J Clin Epidemiol, 2016 Apr5.pii: S0895-4356(16)30066-X.

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