脂联素与血管内皮细胞功能障碍的相关性

Correlation of Adponectin and Vascular Endothelial Cells Dysfunction

代谢综合征的组成成份致冠状动脉粥样硬化性心脏病发生发展的内在机制尚待进一步研究。脂联素作为一种脂肪细胞因子,与内皮依赖性血管舒张功能呈独立正相关,并且是后者的独立决定因素;通过多重信号传导途径上调内皮细胞一氧化氮合成酶活性、增加一氧化氮生成,抑制内皮细胞氧化应激反应、降低细胞损伤程度,阻断内皮细胞炎症信号传导、减轻血管炎症反应。因此,脂联素可能是联系代谢综合征与心血管疾病的枢纽,可以考虑利用脂联素改善代谢综合征患者的血管内皮功能,进而预防或延缓心血管疾病的发生发展。

How components of metabolic syncrome（MS） progress to coronary atherosclerotic heart disease（CAD） is still unclear.Adponectin,a fat-derived plasma protein,is recently considered as a link between MS and CAD,as a number of studies reveal that decreased adiponectin level is associated with impaired endothelial-dependent vasodilation,and adponectin improves endothelial dysfunction through enhancing endothelial nitric oxide（NO） production,suppressing reactive oxygen species generation,and downregulating vascular inflammatory signaling cascade,thus adiponectin may be beneficial to prevention and treatment of MS and CAD.