动脉粥样硬化中的免疫调节

Immunological Regulation in Atherosclerosis

目前已经认识到,动脉粥样硬化是一个由各种免疫细胞启动的炎症反应过程。参与其中的有固有免疫中的单核细胞、巨噬细胞,也有适应性免疫中的T细胞和B细胞,还包括其中的细胞因子。各种免疫细胞在动脉粥样硬化过程中起到的作用是不同的,有的会促进病变的发展,有的会抑制病变的发展。人类单核细胞中的CD14+CD16+细胞具有促炎作用,而有的CD14+CD16-细胞具有抑制炎症的作用;T细胞中的Th1和Th17细胞促进病变的发展,而Th2,CD4+CD25+调节性T细胞则作用相反。近年研究还发现,针对ox-LDL的抗体,对动脉粥样硬化的发生也具有保护作用。因此,深入研究免疫机制会对有效地的防治动脉粥样硬化有指导作用。

To date,atherosclerosis has been considered as an inflammatory process triggered by diverse immune cells.The cells involved in innate immunity such as monocytes and macrophages,adaptive immunity such as T cells and B cells,and cytokines secreted by immune cells all participate in the process.However,the cells involved functions differently with some promoting atherosclerosis while others inhibiting it.In human,CD14＋CD16＋was pro-inflammatory,whereas CD14＋CD16-was anti-inflammatory.Th1and Th17 cells have a pro-atherogenic role,while Th2 and CD4＋CD25＋ regulatory T cells act oppositely.In recent years,antibodies targeting oxLDL were proven athero-protective in studies.It is no doubt that a further understanding of immunological mechanisms in atherosclerosis will guide effective prevention and therapeutics of this disorder.